Scott Alexander, curated
← Back to curation

Things That Sometimes Help If You Have Depression

Quality
74
Strong
Claude Shift
44
Moderate
RWI
3
of 10

Summary

A comprehensive ~6,800-word practical guide from Scott-as-doctor on treating depression: (I) diagnosis (PHQ-9, distinguishing bipolar); (II) the treatment algorithm — rule out organic causes (thyroid/anaemia), SSRI → fiddle/switch → serious (atypical antipsychotics, MAOIs, lithium, modafinil) → very serious (ECT), plus how to find a good psychiatrist and avoid unwanted commitment; (III) lifestyle interventions (CBT workbooks, SLEEP!, exercise, light therapy, avoiding drugs); (IV) supplements (SAM-e, creatine, folate, saffron, fish, modafinil, tianeptine); (V) prognosis. The hammered-home message: if your doctor just gives you one SSRI and it isn't working, there are many other options — don't give up prematurely.

Why this score

Quality 74 · Strong. 74 — high Strong. A top-tier, comprehensive, high-utility public-service guide that is authoritative-yet-humble and directly actionable; frequently linked and genuinely helpful — Score A's usefulness/impact weighting rewards this (comparable to, and slightly broader than, the inpatient-system guide). Held below Excellent because it is instructional rather than a first-order insight.

Claude’s paradigm shift 44 · Moderate. 44 — Moderate. Practical treatment advice synthesised from guidelines, not novel ideas.

Real-world impact 3 · Moderate. 3 — moderate. Among the more directly consequential posts for ordinary readers — people actually use it to navigate depression treatment (push their doctor past the first SSRI, try lifestyle/supplement options) — but reach is limited to readers who need it.